CLOCK anticorps

N° du produit ABIN7261578

Détail du produit anti-CLOCK anticorps

Antigène: CLOCK (Clock Homolog (Mouse) (CLOCK))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLOCK est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human CLOCK (NP_004889.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CLOCK

Antigène: CLOCK (Clock Homolog (Mouse) (CLOCK))

Autre désignation: CLOCK (CLOCK Produits)

Synonymes: anticorps CG7391, anticorps CLK, anticorps CLOCK, anticorps Dmel\\CG7391, anticorps Jerk, anticorps Jrk, anticorps PAS1, anticorps bHLHe10, anticorps clk, anticorps clock, anticorps dCLK, anticorps dCLK/JRK, anticorps dCLOCK, anticorps dClck, anticorps dClk, anticorps dClock, anticorps dclk, anticorps jrk, anticorps Xclk, anticorps XClock, anticorps zCLOCK1, anticorps zfCLOCK1, anticorps 5330400M04Rik, anticorps KAT13D, anticorps bHLHe8, anticorps mKIAA0334, anticorps Clock, anticorps clock circadian regulator, anticorps clock homolog (mouse), anticorps clock circadian regulator a, anticorps circadian locomotor output cycles kaput, anticorps clock circadian regulator L homeolog, anticorps Clk, anticorps CLOCK, anticorps clock, anticorps clocka, anticorps Clock, anticorps clock.L

Sujet: The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Poids moléculaire:

Observed_MW: 110 kDa

Calculated_MW: 95 kDa

ID gène: 9575

UniProt: O15516

Pathways: Regulation of Lipid Metabolism by PPARalpha, Photoperiodism