NPRL2 anticorps

N° du produit ABIN7261820

Détail du produit anti-NPRL2 anticorps

Antigène: NPRL2 (Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPRL2 est non-conjugé

Application: Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human NPRL2 (NP_006536.3).

Isotype: IgG

Information d'application

Indications d'application: IF 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur NPRL2

Antigène: NPRL2 (Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2))

Autre désignation: NPRL2 (NPRL2 Produits)

Synonymes: anticorps 2810446G01Rik, anticorps G21, anticorps NPR2L, anticorps Tusc4, anticorps npr2, anticorps npr2l, anticorps tusc4, anticorps NPR2, anticorps TUSC4, anticorps im:6900399, anticorps zgc:153630, anticorps nitrogen permease regulator-like 2, anticorps NPR2 like, GATOR1 complex subunit S homeolog, anticorps NPR2 like, GATOR1 complex subunit, anticorps NPR2-like, GATOR1 complex subunit, anticorps Nprl2, anticorps nprl2.S, anticorps NPRL2, anticorps nprl2

Sujet: NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events.

ID gène: 10641

UniProt: Q8WTW4