FBXO11 anticorps

N° du produit ABIN7261998

Détail du produit anti-FBXO11 anticorps

Antigène: FBXO11 (F-Box Protein 11 (FBXO11))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXO11 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human FBXO11 (NP_001177203.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IF 1:20-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur FBXO11

Antigène: FBXO11 (F-Box Protein 11 (FBXO11))

Autre désignation: FBXO11 (FBXO11 Produits)

Synonymes: anticorps FBX11, anticorps PRMT9, anticorps UBR6, anticorps VIT1, anticorps C80048, anticorps Jf, anticorps Vit1, anticorps fbxo11, anticorps MGC84634, anticorps FBXO11, anticorps im:6906507, anticorps wu:fj83f06, anticorps zgc:153171, anticorps Fbxo11, anticorps DKFZp459P2410, anticorps F-box protein 11, anticorps F-box protein 11 L homeolog, anticorps F-box protein 11a, anticorps F-box only protein 11, anticorps hypothetical protein, anticorps FBXO11, anticorps Fbxo11, anticorps fbxo11.L, anticorps fbxo11a, anticorps CpipJ_CPIJ009919, anticorps CpipJ_CPIJ017549, anticorps Bm1_52225, anticorps LOAG_16571, anticorps fbxo11, anticorps LOC100115478

Sujet: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Poids moléculaire:

Observed_MW: 130 kDa

Calculated_MW: 23 kDa/62 kDa/65 kDa/94 kDa/103 kDa/106 kDa

ID gène: 80204

UniProt: Q86XK2

Pathways: Sensory Perception of Sound