TRIM33 anticorps (AA 981-1127) (Biotin)

N° du produit ABIN701142

Détail du produit anti-TRIM33 anticorps (Biotin)

Antigène: TRIM33 (Tripartite Motif Containing 33 (TRIM33))

Épitope: AA 981-1127

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM33 est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TIF1 gamma

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur TRIM33

Antigène: TRIM33 (Tripartite Motif Containing 33 (TRIM33))

Autre désignation: T1 gamma (TRIM33 Produits)

Synonymes: anticorps TRIM33, anticorps ptc7, anticorps rfg7, anticorps tf1g, anticorps tif1g, anticorps tifgamma, anticorps MGC146665, anticorps tif1gamma, anticorps ECTO, anticorps PTC7, anticorps RFG7, anticorps TF1G, anticorps TIF1G, anticorps TIF1GAMMA, anticorps TIFGAMMA, anticorps ecto, anticorps 8030451N04Rik, anticorps AI413936, anticorps Ecto, anticorps Tif1g, anticorps ectodermin, anticorps mKIAA1113, anticorps cb1085, anticorps id:ibd2175, anticorps mon, anticorps wu:fc17f10, anticorps zgc:136680, anticorps tripartite motif containing 33, anticorps tripartite motif containing 33 L homeolog, anticorps tripartite motif-containing 33, anticorps TRIM33, anticorps trim33, anticorps trim33.L, anticorps Trim33

Sujet:

Synonyms: ECTO, PTC7, RFG7, TF1G, TIF1G, TIFGAMMA, TIF1GAMMA, E3 ubiquitin-protein ligase TRIM33, Ectodermin homolog, RET-fused gene 7 protein, Protein Rfg7, Transcription intermediary factor 1-gamma, TIF1-gamma, Tripartite motif-containing protein 33, TRIM33, KIAA1113

Background: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

ID gène: 51592

UniProt: Q9UPN9