PARN anticorps

N° du produit ABIN7262849

Détail du produit anti-PARN anticorps

Antigène: PARN (Poly A Specific Ribonuclease (PARN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARN est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human PARN (NP_002573.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IF 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PARN

Antigène: PARN (Poly A Specific Ribonuclease (PARN))

Autre désignation: PARN (PARN Produits)

Synonymes: anticorps parn-A, anticorps xparn, anticorps DAN, anticorps RGD1565449, anticorps zgc:56067, anticorps 1200003I18Rik, anticorps poly(A)-specific ribonuclease L homeolog, anticorps poly(A)-specific ribonuclease, anticorps poly(A)-specific ribonuclease (deadenylation nuclease), anticorps parn.L, anticorps PARN, anticorps Parn, anticorps parn

Sujet: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire:

Observed_MW: 73 kDa

Calculated_MW: 52 kDa/66 kDa/67 kDa/73 kDa

ID gène: 5073

UniProt: O95453