EIF3C anticorps

N° du produit ABIN7262965

Détail du produit anti-EIF3C anticorps

Antigène: EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF3C est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human EIF3C (NP_003743.1).

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200 IF 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur EIF3C

Antigène: EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C))

Autre désignation: EIF3C (EIF3C Produits)

Synonymes: anticorps eif3s8, anticorps fi37c04, anticorps zgc:66128, anticorps wu:fb34a08, anticorps wu:fi37c04, anticorps EIF3S8, anticorps EIF3CL, anticorps eif3-p110, anticorps LOC733086, anticorps eIF3c, anticorps eIF3-S8, anticorps AO090011000340, anticorps eIF3-p110, anticorps 110kDa, anticorps 3230401O13Rik, anticorps Eif3s8, anticorps NIPIL(A3), anticorps NipilA3, anticorps Xs, anticorps Xsl, anticorps EIF3C, anticorps eukaryotic translation initiation factor 3, subunit C, anticorps eukaryotic translation initiation factor 3 subunit C, anticorps eukaryotic translation initiation factor 3 subunit 8, anticorps Eukaryotic translation initiation factor 3 subunit C, anticorps translation initiation factor eIF3c, anticorps translation initiation factor eIF-3 subunit 8, anticorps eukaryotic translation initiation factor 3 subunit C L homeolog, anticorps eukaryotic translation initiation factor 3, subunit C-like, anticorps eif3c, anticorps LOC454016, anticorps LOC479795, anticorps EIF3C, anticorps Smp_000480, anticorps eIF3c, anticorps ANI_1_1094124, anticorps AOR_1_578054, anticorps PTRG_08272, anticorps SJAG_04981, anticorps TERG_03202, anticorps PGTG_09255, anticorps Tsp_05110, anticorps Eif3c, anticorps eif3c.L, anticorps EIF3CL, anticorps eif-3.C

Sujet: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

ID gène: 8663

UniProt: Q99613

Pathways: Ribonucleoprotein Complex Subunit Organization