OAZ1 anticorps

N° du produit ABIN7263455

Détail du produit anti-OAZ1 anticorps

Antigène: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OAZ1 est non-conjugé

Application: Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human OAZ1 (NP_004143.1).

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur OAZ1

Antigène: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Autre désignation: OAZ1 (OAZ1 Produits)

Synonymes: anticorps AZI, anticorps OAZ, anticorps AZ-1, anticorps AZ1, anticorps Antizyme, anticorps ODC-Az, anticorps Oaz, anticorps ODCAC, anticorps oaz, anticorps AZS, anticorps oaz1, anticorps ornithine decarboxylase antizyme 1, anticorps ornithine decarboxylase antizyme 1 S homeolog, anticorps ornithine decarboxylase antizyme 1a, anticorps OAZ1, anticorps Oaz1, anticorps oaz1.S, anticorps oaz1a

Sujet: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.

ID gène: 4946

UniProt: P54368