anticorps IDDM5, anticorps SMT3H4, anticorps SUMO-4, anticorps dJ281H8.4, anticorps small ubiquitin-like modifier 4, anticorps small ubiquitin-related modifier 4, anticorps SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae), anticorps SUMO4, anticorps sumo4
Sujet
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.