anticorps MSS4, anticorps STM7, anticorps AI844522, anticorps Pip5k1a, anticorps Pipk5a, anticorps Pipk5b, anticorps MGC80809, anticorps pip5k1b, anticorps zgc:101046, anticorps wu:fj29b05, anticorps wu:fj93b05, anticorps zgc:92316, anticorps phosphatidylinositol-4-phosphate 5-kinase type 1 beta, anticorps phosphatidylinositol-4-phosphate 5-kinase, type 1 beta, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, beta L homeolog, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, beta a, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, beta, anticorps phosphatidylinositol 4-phosphate 5-kinase type-1 beta, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, beta b, anticorps PIP5K1B, anticorps Pip5k1b, anticorps pip5k1b.L, anticorps pip5k1ba, anticorps pip5k1b, anticorps LOC100472550, anticorps pip5k1bb
Sujet
Phosphatidylinositol-4-phosphate-5-kinase (PIPK) synthesizes phosphatidylinositol-4,5-bisphosphate, which regulates various processes including cell proliferation, survival, membrane trafficking, and cytoskeletal organization. The PIPK family is divided into type I, type II and type III . Each type of the PIPK family phosphorylate distinct substrates and they contain an activation loop, which determines their enzymatic specificity and subcellular targeting . The phosphatidylinositol-4-phosphate-5-kinase type I consists of three members, PIPK I , , and , which are characterized by phosphorylating PI4P on the 5-hydroxyl . PIPK I (designated PIPK I in mouse) is expressed in brain tissue . PIPK I , designated PIPK I a in mouse, is also called STM7. PIPK I has two variants produced by alternative splicing which are expressed in lung, brain, and kidneys.