HSD11B2 anticorps

N° du produit ABIN7264121

Détail du produit anti-HSD11B2 anticorps

Antigène: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD11B2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human HSD11B2 (NP_000187.3).

Isotype: IgG

Information d'application

Indications d'application: WB 1:200-1:1000 IHC 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur HSD11B2

Antigène: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Autre désignation: HSD11B2 (HSD11B2 Produits)

Synonymes: anticorps MGC81883, anticorps 11-HSD2, anticorps AME, anticorps AME1, anticorps HSD11K, anticorps HSD2, anticorps SDR9C3, anticorps 11HSD2, anticorps HSD11B2, anticorps hydroxysteroid (11-beta) dehydrogenase 2 L homeolog, anticorps hydroxysteroid 11-beta dehydrogenase 2, anticorps hsd11b2.L, anticorps HSD11B2, anticorps Hsd11b2

Sujet: There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

Poids moléculaire:

Observed_MW: 44 kDa

Calculated_MW: 44 kDa

ID gène: 3291

UniProt: P80365

Pathways: Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones