PTTG1 anticorps

N° du produit ABIN7264333

Détail du produit anti-PTTG1 anticorps

Antigène: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTTG1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human PTTG1 (NP_001269311.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IHC 1:100-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PTTG1

Antigène: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Autre désignation: PTTG1 (PTTG1 Produits)

Synonymes: anticorps EAP1, anticorps HPTTG, anticorps PTTG, anticorps TUTR1, anticorps PTTG1, anticorps securin, anticorps AW555095, anticorps C87862, anticorps Pttg, anticorps Pttg3, anticorps Securin, anticorps Protein Cut2, anticorps pituitary tumor-transforming 1, anticorps pituitary tumor-transforming gene 1, anticorps securin, sister chromatid separation inhibitor, anticorps PTTG1, anticorps Pttg1, anticorps cut2

Sujet: The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene.

Poids moléculaire:

Observed_MW: 24 kDa

Calculated_MW: 22 kDa

ID gène: 9232

UniProt: O95997