SIGLEC12 anticorps

N° du produit ABIN7264571

Détail du produit anti-SIGLEC12 anticorps

Antigène: SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIGLEC12 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human SIGLEC12 (NP_443729.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SIGLEC12

Antigène: SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))

Autre désignation: SIGLEC12 (SIGLEC12 Produits)

Synonymes: anticorps S2V, anticorps SIGLECL1, anticorps SLG, anticorps Siglec-XII, anticorps sialic acid binding Ig like lectin 12 (gene/pseudogene), anticorps sialic acid binding Ig like lectin 12, anticorps sialic acid binding Ig-like lectin 12, anticorps SIGLEC12

Sujet: Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants.

Poids moléculaire:

Observed_MW: 80 kDa

Calculated_MW: 51 kDa/64 kDa

ID gène: 89858

UniProt: Q96PQ1