FLASH anticorps (AA 1861-1982)

N° du produit ABIN702220

Détail du produit anti-FLASH anticorps

Antigène: FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))

Épitope: AA 1861-1982

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FLASH est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FLASH/CASP8AP2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur FLASH

Antigène: FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))

Autre désignation: FLASH/CASP8AP2 (CASP8AP2 Produits)

Synonymes: anticorps CASP8AP2, anticorps FLASH, anticorps fc74h10, anticorps wu:fc74h10, anticorps zgc:113449, anticorps CED-4, anticorps RIP25, anticorps AA387232, anticorps D4Ertd659e, anticorps mKIAA1315, anticorps caspase 8 associated protein 2, anticorps CASP8AP2, anticorps casp8ap2, anticorps Casp8ap2

Sujet:

Synonyms: CASP 8 associated protein 2, CASP8 associated protein 2, CASP8AP2, Caspase 8 associated protein 2, CED 4, CED4, FLASH homolog, FLASH homolog RIP 25, FLASH homolog RIP25, FLICE associated huge, FLICE associated huge protein, FLICE-associated huge protein, RIP 25, RIP25, AA387232, D4Ertd659e, mKIAA1315, C8AP2_HUMAN, CASP8-associated protein 2, FLICE-associated huge protein, FLJ11208, KIAA1315, OTTMUSP00000005125, RP23-69G24.1.

Background: FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.Studies of FLASH protein suggested that this protein may be a component of the death inducing signaling complex that includes Fas receptor, Fas binding adapter FADD, and caspase 8, and plays a regulatory role in Fas mediated apoptosis.

ID gène: 9994

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity