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Recombinant CCR5 anticorps (pSer349)

CCR5 Reactivité: Humain WB, ELISA, IF, IP Hôte: Lapin Chimeric E11-19 unconjugated Recombinant Antibody
N° du produit ABIN7072657
  • Antigène Voir toutes CCR5 Anticorps
    CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
    Type d'anticorp
    Recombinant Antibody
    Épitope
    • 16
    • 12
    • 10
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    • 7
    • 6
    • 6
    • 5
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    pSer349
    Reactivité
    • 166
    • 50
    • 36
    • 10
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 103
    • 48
    • 22
    • 6
    • 3
    Lapin
    Clonalité
    • 102
    • 75
    • 2
    Chimeric
    Conjugué
    • 92
    • 15
    • 12
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
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    Cet anticorp CCR5 est non-conjugé
    Application
    • 94
    • 83
    • 70
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    • 26
    • 18
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    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)
    Fonction
    Anti-CCR5 (phosphoserine 349) [E11/19], Rabbit IgG, kappa
    Specificité
    The E11/19 monoclonal antibody binds to phosphoserine 349 corresponding to 22 c-terminal amino acid residue of human CCR5. CCR5 is a receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES.
    Attributs du produit

    Original Species of Ab: Mouse

    Original Format of Ab: IgG1

    Purification
    Protein A affinity purified
    Immunogène
    This antibody was raised by immunizing mice with a synthetic phosphopeptide (CEAPERA(pS)(pS)VYTR(pS)TGEQI(pS)VGL) corresponding to the C-terminal region of human CCR5.
    Clone
    E11-19
    Isotype
    IgG kappa
    Top Product
    Discover our top product CCR5 Anticorps primaire
  • Indications d'application
    The E11/19 antibody is recommended for for flow cytometric analysis, immunoblotting, and ELISA assay of CCR5 expression. It was also successfully utilized in the immunoprecipitation of CCR5 (Venuti et al., 2016). This antibody was demonstrated to detect pS349 CCR5 via Western blot when it was first activated to its phosphorylated form (Pollok-Kopp et al., 2003). Furthermore, E11/19 antibody was used to identify the localization of pS349 CCR5 in RBL cells via immunofluorescence (Pollok-Kopp et al., 2003). With other anti-CCR5 antibodies which react with nonphosporylated CCR5 (Ab01577) or CCR5 phosphorylated on different serine residues (Ab01579), it can be used to study dynamic regulation of CCR5 and of phosphorylation mechanisms.
    Commentaires

    This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % Proclin 300.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Antigène
    CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
    Autre désignation
    CCR5 (CCR5 Produits)
    Sujet
    CD195, C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CHEMR13, HIV-1 fusion coreceptor, p349, pS349, Ser-349, Ser349
    UniProt
    P51681
    Pathways
    Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
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