B-Cell Linker anticorps
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- Antigène Voir toutes B-Cell Linker (BLNK) Anticorps
- B-Cell Linker (BLNK)
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Reactivité
- Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp B-Cell Linker est non-conjugé
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Application
- Immunohistochemistry (IHC), Immunofluorescence (IF)
- Réactivité croisée
- Rat
- Purification
- Affinity purification
- Immunogène
- Recombinant protein corresponding to Mouse BLNK
- Top Product
- Discover our top product BLNK Anticorps primaire
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- Indications d'application
- IHC/IF (M,R) 1:2500-1:5000/1:1500-1:2500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
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- Antigène
- B-Cell Linker (BLNK)
- Autre désignation
- BLNK (BLNK Produits)
- Synonymes
- anticorps BLNK, anticorps blnk, anticorps MGC147045, anticorps BASH, anticorps Bca, anticorps Ly-57, anticorps Ly57, anticorps Lyw-57, anticorps SLP-65, anticorps AGM4, anticorps BLNK-S, anticorps LY57, anticorps SLP65, anticorps bca, anticorps B-cell linker, anticorps B cell linker, anticorps BLNK, anticorps blnk, anticorps Blnk
- Sujet
- The function of BLNK was first illustrated in BLNK deficient DT40 cells, a chicken B-cell line, which exhibited an abrogated intracellular calcium mobilisation response and impaired activation of MAP kinases p38, JNK, and to a lesser degree ERK upon B-cell receptor (BCR) activation as compared to wild type DT40 cells. In knockout mice, BLNK deficiency results in a partial block in B-cell development, and in humans BLNK deficiency results in a much more profound block in B-cell development. Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.
- ID gène
- 17060
- NCBI Accession
- NP_032554
- UniProt
- Q9QUN3
- Pathways
- BCR Signaling
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