BPTF anticorps

N° du produit ABIN7073234

Détail du produit anti-BPTF anticorps

Antigène: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BPTF est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Souris, Rat

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Human BPTF

Information d'application

Indications d'application: IHC/IF (H,M,R) 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur BPTF

Antigène: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Autre désignation: BPTF/FALZ (BPTF Produits)

Sujet: FALZ/BPTF is a histone-binding component of NURF (nucleosome remodeling factor), a complex that catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. This gene was identified in brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), containing a DNA-binding domain, a zinc finger motif, and a C-terminal bromodomain, suggested it might play a role in the regulation of transcription during proliferation. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. This protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription.

ID gène: 2186

NCBI Accession: NP_004450

UniProt: Q12830