CYB561 anticorps

N° du produit ABIN7073661

Détail du produit anti-CYB561 anticorps

Antigène: CYB561 (Cytochrome B-561 (CYB561))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYB561 est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (IHC)

Réactivité croisée: Rat

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Mouse Pyruvate Dehydrogenase E2

Information d'application

Indications d'application: IHC/IF (R) 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur CYB561

Antigène: CYB561 (Cytochrome B-561 (CYB561))

Autre désignation: Pyruvate Dehydrogenase E2 (CYB561 Produits)

Synonymes: anticorps CYB561A1, anticorps FRRS2, anticorps ECK1410, anticorps JW5224, anticorps MGC69260, anticorps zgc:193680, anticorps zgc:193701, anticorps ACYB-1, anticorps MBB18.18, anticorps MBB18_18, anticorps cytochrome B561-1, anticorps xcyt, anticorps cytochrome b561, anticorps cytochrome b-561, anticorps cytochrome B561-1, anticorps cytochrome b561 L homeolog, anticorps CYB561, anticorps cytb561, anticorps cybB, anticorps LOC5576849, anticorps LOC5576850, anticorps Cyb561, anticorps cyb561, anticorps CYB-1, anticorps cyb561.L, anticorps LOC100347599

Sujet: This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95 % of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure.

ID gène: 235339

UniProt: Q8BMF4