GDF5 anticorps
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- Antigène Voir toutes GDF5 Anticorps
- GDF5 (Growth Differentiation Factor 5 (GDF5))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GDF5 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Réactivité croisée
- Humain, Rat
- Purification
- Affinity purification
- Immunogène
- KLH conjugated Synthetic peptide corresponding to Mouse GDF 5
- Top Product
- Discover our top product GDF5 Anticorps primaire
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- Indications d'application
- WB (H,M) 1:500-1:1000, IHC/IF (H,R) 1:200-1:400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
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- Antigène
- GDF5 (Growth Differentiation Factor 5 (GDF5))
- Autre désignation
- GDF 5 (GDF5 Produits)
- Synonymes
- anticorps CDMP1, anticorps gdf, anticorps gdf-5, anticorps GDF5, anticorps BDA1C, anticorps BMP14, anticorps LAP4, anticorps OS5, anticorps SYM1B, anticorps SYNS2, anticorps Cdmp-1, anticorps bp, anticorps brp, anticorps Cdmp1, anticorps growth differentiation factor 5 L homeolog, anticorps growth differentiation factor 5, anticorps gdf5.L, anticorps GDF5, anticorps Gdf5
- Sujet
- Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction . Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG . Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 .
- Poids moléculaire
- 55 kDa
- ID gène
- 14563
- NCBI Accession
- NP_032135
- UniProt
- P43027
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