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H2-AB1 anticorps

H2-AB1 Reactivité: Souris, Rat IF, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7074228
  • Antigène Tous les produits H2-AB1
    H2-AB1 (Histocompatibility 2, Class II Antigen A, beta 1 (H2-AB1))
    Reactivité
    Souris, Rat
    Hôte
    • 1
    Lapin
    Clonalité
    • 1
    Polyclonal
    Conjugué
    • 1
    Cet anticorp H2-AB1 est non-conjugé
    Application
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Immunohistochemistry (IHC)
     Réactivité croisée
    Rat
    Purification
    Affinity purification
    Immunogène
    Recombinant protein corresponding to Mouse H2ab1
  • Indications d'application
    IHC/IF (M,R) 1:4000-1:8800
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS, pH 7.4, 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Antigène
    H2-AB1 (Histocompatibility 2, Class II Antigen A, beta 1 (H2-AB1))
    Autre désignation
    H2ab1 (H2-AB1 Produits)
    Synonymes
    anticorps AI845868, anticorps Abeta, anticorps H-2Ab, anticorps H2-Ab, anticorps I-Abeta, anticorps IAb, anticorps Ia-2, anticorps Ia2, anticorps Rmcs1, anticorps histocompatibility 2, class II antigen A, beta 1, anticorps H2-Ab1
    Sujet
    Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells . Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template . Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes . In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes . Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) .
    ID gène
    68231
    NCBI Accession
    NP_080903
    UniProt
    Q9CQ70
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