anticorps THEM4, anticorps CTMP, anticorps 2700077M13Rik, anticorps 4921507I02Rik, anticorps RGD1304723, anticorps thioesterase superfamily member 4, anticorps thioesterase superfamily member 4 L homeolog, anticorps THEM4, anticorps them4, anticorps Them4, anticorps them4.L
Sujet
THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer.