TCF7 anticorps

N° du produit ABIN7075952

Détail du produit anti-TCF7 anticorps

Antigène: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TCF7 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Rat

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Mouse TCF7

Information d'application

Indications d'application: IHC/IF (M,R) 1:600-1:1200/1:600-1:1200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur TCF7

Antigène: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Autre désignation: TCF7 (TCF7 Produits)

Synonymes: anticorps TCF-1, anticorps AI465550, anticorps Tcf1, anticorps Xtcf-1, anticorps Xtcf1, anticorps tcf-1, anticorps tcf1, anticorps tcf7, anticorps transcription factor 7, anticorps transcription factor 7, T cell specific, anticorps transcription factor 7 S homeolog, anticorps TCF7, anticorps Tcf7, anticorps tcf7, anticorps tcf7.S

Sujet: TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

ID gène: 21414

NCBI Accession: NP_001300910

UniProt: Q00417

Pathways: Signalisation WNT