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WDR81 anticorps

WDR81 Reactivité: Humain, Souris, Rat WB, IF, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7076221
  • Antigène Voir toutes WDR81 Anticorps
    WDR81 (WD Repeat Domain 81 (WDR81))
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 3
    Lapin
    Clonalité
    • 3
    Polyclonal
    Conjugué
    • 3
    Cet anticorp WDR81 est non-conjugé
    Application
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
     Réactivité croisée
    Humain, Rat
    Purification
    Affinity purification
    Immunogène
    Recombinant protein corresponding to Mouse WDR81
  • Indications d'application
    WB (H,M,R) 1:1000- 1:2000, IHC/IF (M,R) 1:700-1:1400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS, pH 7.4, 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Antigène
    WDR81 (WD Repeat Domain 81 (WDR81))
    Autre désignation
    WDR81 (WDR81 Produits)
    Synonymes
    anticorps CAMRQ2, anticorps BC054822, anticorps Gm883, anticorps mFLJ00182, anticorps WD repeat domain 81, anticorps WDR81, anticorps Wdr81
    Sujet
    This gene functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (By similarity). May also be involved in maintenance of normal mitochondrial structure and organization.
    Poids moléculaire
    65 kDa
    ID gène
    192652
    NCBI Accession
    NP_620400
    UniProt
    Q5ND34
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