anticorps B330005D23Rik, anticorps FOG-2, anticorps FOG2, anticorps DIH3, anticorps ZC2HC11B, anticorps ZNF89B, anticorps hFOG-2, anticorps FOG-A, anticorps fog2a, anticorps zgc:152696, anticorps zinc finger protein, multitype 2, anticorps zinc finger protein, FOG family member 2, anticorps zinc finger protein, FOG family member 2a, anticorps Zfpm2, anticorps ZFPM2, anticorps zfpm2a
Sujet
FOG-2 is the transcriptional cofactors of FOG family . FOG-2 is able to both positively and negatively influence GATA mediated transcription. FOG-2 is predominantly expressed in heart, neurons and gonads, and it preferentially participates in the regulation of GATA-3, GATA-4 and GATA-6. In cardiomyocytes and fibroblasts, FOG-2 inhibits GATA-4 transcriptional activity, yet FOG-2 restores GATA-1 mediated transcription in erythroid cultures deficient in FOG, suggesting that the observed effects of FOG-2 are context specific and vary between cellular systems.