PABP anticorps (meArg455, meArg460) (Biotin)

N° du produit ABIN704833

Détail du produit anti-PABP anticorps (Biotin)

Antigène: PABP (PABPC1) (Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1))

Épitope: meArg455, meArg460

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PABP est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris, Rat

Homologie: Human,Cow,Pig,Horse,Chicken,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic metylpeptide derived from human PABP around metylation site of Arg455/Arg460

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur PABP

Antigène: PABP (PABPC1) (Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1))

Autre désignation: Pabp (PABPC1 Produits)

Synonymes: anticorps PAB1, anticorps PABP, anticorps PABP1, anticorps PABPC2, anticorps PABPL1, anticorps Pabp1, anticorps PabpI, anticorps Pabpl1, anticorps ePAB, anticorps Pabp, anticorps pab1, anticorps pabp, anticorps pabp1, anticorps pabpc1, anticorps pabpc2, anticorps PABPC1, anticorps wu:fb16a02, anticorps wu:fi19b08, anticorps wu:fj12d09, anticorps wu:fj61f06, anticorps zgc:109879, anticorps zgc:77608, anticorps poly(A) binding protein cytoplasmic 1, anticorps poly(A) binding protein, cytoplasmic 1, anticorps poly(A) binding protein, cytoplasmic 1 S homeolog, anticorps poly(A) binding protein cytoplasmic 1 like, anticorps poly(A) binding protein, cytoplasmic 1 L homeolog, anticorps poly(A) binding protein, cytoplasmic 1a, anticorps poly A binding protein, cytoplasmic 1 b, anticorps PABPC1, anticorps Pabpc1, anticorps pabpc1.S, anticorps pabpc1, anticorps PABPC1L, anticorps pabpc1.L, anticorps pabpc1a, anticorps pabpc1b

Sujet:

Synonyms: PAB1, PABP, PABP1, PABPC2, PABPL1, Polyadenylate-binding protein 1, PABP-1, Poly(A)-binding protein 1, PABPC1

Background: Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.

ID gène: 26986

UniProt: P11940

Pathways: SARS-CoV-2 Protein Interactome