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CHMP1A anticorps (AA 51-150)

CHMP1A Reactivité: Humain, Souris IHC (fro), IHC (p), IF (cc), IF (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN705236
  • Antigène Voir toutes CHMP1A Anticorps
    CHMP1A (Charged Multivesicular Body Protein 1A (CHMP1A))
    Épitope
    • 8
    • 8
    • 7
    • 6
    • 1
    AA 51-150
    Reactivité
    • 35
    • 12
    • 2
    Humain, Souris
    Hôte
    • 31
    • 4
    Lapin
    Clonalité
    • 35
    Polyclonal
    Conjugué
    • 14
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CHMP1A est non-conjugé
    Application
    • 24
    • 19
    • 5
    • 4
    • 1
    • 1
    Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris
    Homologie
    Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human CHMP1A
    Isotype
    IgG
    Top Product
    Discover our top product CHMP1A Anticorps primaire
  • Indications d'application
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    CHMP1A (Charged Multivesicular Body Protein 1A (CHMP1A))
    Autre désignation
    CHMP1A (CHMP1A Produits)
    Synonymes
    anticorps CHMP1, anticorps PCH8, anticorps PCOLN3, anticorps PRSM1, anticorps VPS46-1, anticorps VPS46A, anticorps 2900018H07Rik, anticorps Pcoln3, anticorps charged multivesicular body protein 1A, anticorps CHMP1A, anticorps Chmp1a
    Sujet

    Synonyms: PCH8, CHMP1, PRSM1, PCOLN3, VPS46A, VPS46-1, Charged multivesicular body protein 1a, Chromatin-modifying protein 1a, CHMP1a, Vacuolar protein sorting-associated protein 46-1, hVps46-1, KIAA0047

    Background: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

    ID gène
    5119
    UniProt
    Q9HD42
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