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PDIA2 anticorps (AA 431-525)

PDIA2 Reactivité: Souris, Rat ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN705881
  • Antigène Voir toutes PDIA2 Anticorps
    PDIA2 (Protein Disulfide Isomerase Family A, Member 2 (PDIA2))
    Épitope
    • 14
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 431-525
    Reactivité
    • 33
    • 27
    • 20
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Souris, Rat
    Hôte
    • 50
    • 4
    • 1
    Lapin
    Clonalité
    • 54
    • 1
    Polyclonal
    Conjugué
    • 19
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PDIA2 est non-conjugé
    Application
    • 43
    • 26
    • 12
    • 12
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Souris, Rat
    Homologie
    Human
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human PDIA2
    Isotype
    IgG
    Top Product
    Discover our top product PDIA2 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    PDIA2 (Protein Disulfide Isomerase Family A, Member 2 (PDIA2))
    Autre désignation
    PDIA2 (PDIA2 Produits)
    Synonymes
    anticorps PDIA2, anticorps DKFZp468D2220, anticorps 1810041F13Rik, anticorps AI661267, anticorps Pdip, anticorps Pdipl, anticorps PDA2, anticorps PDI, anticorps PDIP, anticorps PDIR, anticorps protein disulfide isomerase family A member 2, anticorps protein disulfide isomerase associated 2, anticorps protein disulfide isomerase family A, member 2, anticorps PDIA2, anticorps Pdia2
    Sujet

    Synonyms: Pancreatic protein disulfide isomerase, PDA2, PDI, PDIA2, PDIP, Protein disulfide isomerase A2, Protein disulfide isomerase, Protein disulfide isomerase family A member 2, PDIA2_HUMAN.

    Background: The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

    ID gène
    64714
    Pathways
    Maintenance of Protein Location, Cell RedoxHomeostasis, Unfolded Protein Response
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