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RNF4 anticorps

RNF4 Reactivité: Humain WB Hôte: Souris Monoclonal E4R2 unconjugated
N° du produit ABIN7091651
  • Antigène Voir toutes RNF4 Anticorps
    RNF4 (Ring Finger Protein 4 (RNF4))
    Reactivité
    • 18
    • 3
    • 2
    Humain
    Hôte
    • 18
    • 1
    Souris
    Clonalité
    • 19
    Monoclonal
    Conjugué
    • 12
    • 3
    • 2
    • 2
    Cet anticorp RNF4 est non-conjugé
    Application
    • 10
    • 9
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    Human
    Immunogène
    Recombinant human RNF4.
    Clone
    E4R2
    Top Product
    Discover our top product RNF4 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    Restrictions
    For Research Use only
  • Concentration
    0.5 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    RNF4 (Ring Finger Protein 4 (RNF4))
    Autre désignation
    RNF4 (RNF4 Produits)
    Synonymes
    anticorps SLX5, anticorps SNURF, anticorps AU018689, anticorps Gtrgeo8, anticorps ring finger protein 4, anticorps RNF4, anticorps Rnf4
    Sujet

    Synonyms: RNF4_HUMAN, E3 ubiquitin ligase RNF4, E3 ubiquitin protein ligase RNF4, Protein SNURF, RES4 26, RING finger protein 4, SLX5, Small nuclear ring finger protein, SNURF.

    Background: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

    ID gène
    6047
    UniProt
    P78317
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway
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