RNF4 anticorps

N° du produit ABIN7091651

Détail du produit anti-RNF4 anticorps

Antigène: RNF4 (Ring Finger Protein 4 (RNF4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RNF4 est non-conjugé

Application: Western Blotting (WB)

Homologie: Human

Immunogène: Recombinant human RNF4.

Clone: E4R2

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur RNF4

Antigène: RNF4 (Ring Finger Protein 4 (RNF4))

Autre désignation: RNF4 (RNF4 Produits)

Synonymes: anticorps SLX5, anticorps SNURF, anticorps AU018689, anticorps Gtrgeo8, anticorps ring finger protein 4, anticorps RNF4, anticorps Rnf4

Sujet:

Synonyms: RNF4_HUMAN, E3 ubiquitin ligase RNF4, E3 ubiquitin protein ligase RNF4, Protein SNURF, RES4 26, RING finger protein 4, SLX5, Small nuclear ring finger protein, SNURF.

Background: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

ID gène: 6047

UniProt: P78317

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway