anticorps AFAR, anticorps AFAR1, anticorps AFB1-AR1, anticorps AKR7, anticorps Aiar, anticorps akr7a2, anticorps aldo-keto reductase family 7 member A2, anticorps aldo-keto reductase family 7, member A2, anticorps aldo-keto reductase family 7, member A2 L homeolog, anticorps AKR7A2, anticorps Akr7a2, anticorps akr7a2.L
Sujet
Synonyms:AFAR, AFAR1, AFB1 aldehyde reductase 1, AFB1 AR 1, AFB1 AR1, AKR7, AKR7A2, Aldoketoreductase 7, SSA reductase Background:The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants.