CALCOCO2 anticorps

N° du produit ABIN7112166

Détail du produit anti-CALCOCO2 anticorps

Antigène: CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CALCOCO2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: calcium binding and coiled-coil domain 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:500-1:1000, IHC: 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur CALCOCO2

Antigène: CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))

Autre désignation: CALCOCO2 (CALCOCO2 Produits)

Synonymes: anticorps CALCOCO2, anticorps MGC110205, anticorps wu:fj08c01, anticorps zgc:110205, anticorps DKFZp469D2219, anticorps NDP52, anticorps 2410154J16Rik, anticorps C77254, anticorps Ndp52, anticorps Ndp52l1, anticorps RGD1559974, anticorps calcium binding and coiled-coil domain 2, anticorps CALCOCO2, anticorps calcoco2, anticorps Calcoco2

Sujet: Synonyms:NDP52 Background:Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy(PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation(PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C(PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion(PubMed:17635994).

Poids moléculaire: 52 kDa

ID gène: 10241

UniProt: Q13137