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CARD9 anticorps

CARD9 Reactivité: Humain, Souris, Rat WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7112379
  • Antigène Voir toutes CARD9 Anticorps
    CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))
    Reactivité
    • 40
    • 3
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 38
    • 3
    Lapin
    Clonalité
    • 40
    • 1
    Polyclonal
    Conjugué
    • 21
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CARD9 est non-conjugé
    Application
    • 34
    • 13
    • 13
    • 9
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    Immunogen affinity purified
    Pureté
    ≥95 % as determined by SDS-PAGE
    Immunogène
    caspase recruitment domain family, member 9
    Isotype
    IgG
    Top Product
    Discover our top product CARD9 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Date de péremption
    12 months
  • Antigène
    CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))
    Autre désignation
    CARD9 (CARD9 Produits)
    Synonymes
    anticorps Gm782, anticorps card9, anticorps CANDF2, anticorps hCARD9, anticorps caspase recruitment domain family, member 9, anticorps caspase recruitment domain family member 9, anticorps Card9, anticorps CARD9, anticorps card9
    Sujet
    Synonyms: Background:Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors(TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases(MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B(By similarity). Controls CLEC7A(dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A(dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper(TH-17) cells.
    Poids moléculaire
    50-59kd
    ID gène
    64170
    UniProt
    Q9H257
    Pathways
    Activation of Innate immune Response
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