CBLC anticorps

N° du produit ABIN7112417

Détail du produit anti-CBLC anticorps

Antigène: CBLC (Cbl proto-oncogene C (CBLC))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBLC est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: Cas-Br-M(murine) ecotropic retroviral transforming sequence c

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur CBLC

Antigène: CBLC (Cbl proto-oncogene C (CBLC))

Autre désignation: CBLC (CBLC Produits)

Synonymes: anticorps CBL-3, anticorps CBL-SL, anticorps RNF57, anticorps Cbl proto-oncogene C, anticorps CBLC, anticorps Cblc

Sujet: Synonyms:CBL3, RNF57 Background:Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction, upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation, CD2AP converts it from an inhibitor to a promoter of RET degradation, the function limits the potency of GDNF on neuronal survival.

Poids moléculaire: 52kd

ID gène: 23624

UniProt: Q9ULV8

Pathways: EGFR Signaling Pathway