CEP63 anticorps

N° du produit ABIN7112613

Détail du produit anti-CEP63 anticorps

Antigène: CEP63 (Centrosomal Protein 63kDa (CEP63))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CEP63 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: centrosomal protein 63kDa

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur CEP63

Antigène: CEP63 (Centrosomal Protein 63kDa (CEP63))

Autre désignation: CEP63 (CEP63 Produits)

Synonymes: anticorps 4921501M07, anticorps AL450317.13gm1, anticorps AW107703, anticorps CD20R, anticorps D9Mgc41, anticorps D9Mgc48e, anticorps ET2, anticorps zgc:63548, anticorps Cep63-A, anticorps Cep63-B, anticorps Xcep63, anticorps centrosomal protein 63, anticorps centrosomal protein 63kDa, anticorps centrosomal protein 63kDa L homeolog, anticorps CEP63, anticorps SYO3AOP1_1060, anticorps Cep63, anticorps cep63, anticorps cep63.L

Sujet: Synonyms: Background:Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication, the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152, however, this function has been questioned(PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes(PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks(DSBs), is removed from centrosomes, this leads to the inactivation of spindle assembly and delay in mitotic progression(PubMed:21406398).

Poids moléculaire: 57-75kd

ID gène: 80254

UniProt: Q96MT8

Pathways: M Phase