COPS7A anticorps

N° du produit ABIN7113043

Détail du produit anti-COPS7A anticorps

Antigène: COPS7A (COP9 Signalosome Complex Subunit 7a (COPS7A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS7A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: COP9 constitutive photomorphogenic homolog subunit 7A(Arabidopsis)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur COPS7A

Antigène: COPS7A (COP9 Signalosome Complex Subunit 7a (COPS7A))

Autre désignation: COPS7A (COPS7A Produits)

Synonymes: anticorps D6Ertd35e, anticorps CSN7A, anticorps COP9 signalosome subunit 7A, anticorps COPS7A, anticorps Cops7a

Sujet: Synonyms:CSN7A, DERP10 Background:Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Poids moléculaire: 30 kDa

ID gène: 50813

UniProt: Q9UBW8

Pathways: Cycle Cellulaire