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CDKN1B anticorps

CDKN1B Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7113177
  • Antigène Voir toutes CDKN1B Anticorps
    CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
    Reactivité
    • 270
    • 125
    • 105
    • 26
    • 8
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 234
    • 49
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 230
    • 57
    Polyclonal
    Conjugué
    • 137
    • 24
    • 17
    • 16
    • 16
    • 14
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CDKN1B est non-conjugé
    Application
    • 197
    • 133
    • 71
    • 60
    • 50
    • 41
    • 31
    • 26
    • 20
    • 16
    • 16
    • 11
    • 7
    • 7
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Purification
    Immunogen affinity purified
    Pureté
    ≥95 % as determined by SDS-PAGE
    Immunogène
    cyclin-dependent kinase inhibitor 1B(p27, Kip1)
    Isotype
    IgG
    Top Product
    Discover our top product CDKN1B Anticorps primaire
  • Indications d'application
    WB: 1:200-1:2000, IP: 1:200-1:1000, IHC: 1:50-1:500, IF: 1:50-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Date de péremption
    12 months
  • Antigène
    CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
    Autre désignation
    P27, KIP1 (CDKN1B Produits)
    Synonymes
    anticorps CDKN4, anticorps KIP1, anticorps MEN1B, anticorps MEN4, anticorps P27KIP1, anticorps cdkn1b, anticorps sb:cb611, anticorps wu:fb63g10, anticorps wu:fb64g10, anticorps wu:fe18e03, anticorps CDKN1B, anticorps Kip1, anticorps p27, anticorps FAM14D, anticorps ISG12, anticorps ISG12A, anticorps P27, anticorps Cdki1b, anticorps AA408329, anticorps AI843786, anticorps p27Kip1, anticorps cdkn1bl, anticorps cyclin dependent kinase inhibitor 1B, anticorps cyclin-dependent kinase inhibitor 1Bb, anticorps interferon alpha inducible protein 27, anticorps cyclin-dependent kinase inhibitor 1B, anticorps cyclin-dependent kinase inhibitor 1Ba, anticorps CDKN1B, anticorps cdkn1bb, anticorps IFI27, anticorps Cdkn1b, anticorps cdkn1ba
    Sujet
    Synonyms:CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27, P27, KIP1, P27KIP1 Background:CDKN1B, also named as P27 or KIP1, is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. P27 binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controlling cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Downregulation of P27 has been implicated in the progression of several malignancies, including lung cancer, hepatocellular carcinoma, salivary cancer, oral squamous cell carcinomas, and gastric cancer.
    Poids moléculaire
    27 kDa
    ID gène
    1027
    UniProt
    P46527
    Pathways
    Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy
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