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DNA2 anticorps

DNA2 Reactivité: Humain, Souris ELISA, IHC, WB, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7113557
  • Antigène Voir toutes DNA2 Anticorps
    DNA2 (DNA Replication Helicase 2 Homolog (DNA2))
    Reactivité
    • 19
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 19
    Lapin
    Clonalité
    • 19
    Polyclonal
    Conjugué
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DNA2 est non-conjugé
    Application
    • 9
    • 6
    • 5
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)
    Purification
    Immunogen affinity purified
    Pureté
    ≥95 % as determined by SDS-PAGE
    Immunogène
    DNA replication helicase 2 homolog
    Isotype
    IgG
    Top Product
    Discover our top product DNA2 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:1000, IHC: 1:50-1:500, IF: 1:10-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Date de péremption
    12 months
  • Antigène
    DNA2 (DNA Replication Helicase 2 Homolog (DNA2))
    Autre désignation
    DNA2 (DNA2 Produits)
    Synonymes
    anticorps DNA2L, anticorps Dna2l, anticorps E130315B21Rik, anticorps PEOA6, anticorps hDNA2, anticorps XDna2, anticorps dna2-A, anticorps DNA replication helicase/nuclease 2, anticorps DNA replication helicase/nuclease 2 S homeolog, anticorps DNA2, anticorps Dna2, anticorps dna2.S
    Sujet
    Synonyms:DNA2, DNA2L, KIAA0083 Background:Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex(RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break(DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA(ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.
    Poids moléculaire
    127 kDa
    ID gène
    1763
    UniProt
    P51530
    Pathways
    Telomere Maintenance, Réparation de l'ADN, DNA Replication, Synthesis of DNA
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