EXOSC4 anticorps

N° du produit ABIN7114013

Détail du produit anti-EXOSC4 anticorps

Antigène: EXOSC4 (Exosome Component 4 (EXOSC4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EXOSC4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: exosome component 4

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur EXOSC4

Antigène: EXOSC4 (Exosome Component 4 (EXOSC4))

Autre désignation: EXOSC4 (EXOSC4 Produits)

Synonymes: anticorps EXOSC4, anticorps zgc:73175, anticorps RRP41, anticorps RRP41A, anticorps Rrp41p, anticorps SKI6, anticorps Ski6p, anticorps hRrp41p, anticorps p12A, anticorps 1110039I09Rik, anticorps 1500001N04Rik, anticorps Rrp41, anticorps exosome component 4, anticorps exosome component 4 S homeolog, anticorps exosc4, anticorps EXOSC4, anticorps CC1G_03561, anticorps exosc4.S, anticorps Exosc4

Sujet: Synonyms:RRP41, SKI6 Background:Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.

Poids moléculaire: 27kd

ID gène: 54512

UniProt: Q9NPD3