FBXW11 anticorps

N° du produit ABIN7114038

Détail du produit anti-FBXW11 anticorps

Antigène: FBXW11 (F-Box and WD Repeat Domain Containing 11 (FBXW11))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXW11 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: F-box and WD repeat domain containing 11

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur FBXW11

Antigène: FBXW11 (F-Box and WD Repeat Domain Containing 11 (FBXW11))

Autre désignation: FBXW11 (FBXW11 Produits)

Synonymes: anticorps BTRC2, anticorps BTRCP2, anticorps FBW1B, anticorps FBXW1B, anticorps Fbw11, anticorps Hos, anticorps 2310065A07Rik, anticorps AA536858, anticorps Fbxw1b, anticorps HOS, anticorps btrc2, anticorps fbxw11a, anticorps wu:fa12e12, anticorps wu:fb11f03, anticorps zgc:63728, anticorps fbxw11, anticorps fbxw11b, anticorps fbxw1b, anticorps wu:fd14d12, anticorps wu:fi43f07, anticorps F-box and WD repeat domain containing 11, anticorps F-box and WD-40 domain protein 11, anticorps F-box/WD repeat-containing protein 11, anticorps F-box and WD repeat domain containing 11b, anticorps F-box and WD repeat domain containing 11a, anticorps FBXW11, anticorps Fbxw11, anticorps LOC100199403, anticorps fbxw11b, anticorps fbxw11a

Sujet: Synonyms:BTRCP2, FBW1B, FBXW1B, KIAA0696 Background:Substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68, this is required for centriole separation during mitosis(PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1(HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.

Poids moléculaire: 61 kDa

ID gène: 23291

UniProt: Q9UKB1