GEMIN5 anticorps

N° du produit ABIN7114527

Détail du produit anti-GEMIN5 anticorps

Antigène: GEMIN5 (Gem (Nuclear Organelle) Associated Protein 5 (GEMIN5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GEMIN5 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: gem(nuclear organelle) associated protein 5

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000, IP: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur GEMIN5

Antigène: GEMIN5 (Gem (Nuclear Organelle) Associated Protein 5 (GEMIN5))

Autre désignation: GEMIN5 (GEMIN5 Produits)

Synonymes: anticorps GEMIN-5, anticorps AA407055, anticorps AA407208, anticorps AI451603, anticorps BB194447, anticorps C330013N08, anticorps gem nuclear organelle associated protein 5, anticorps gem (nuclear organelle) associated protein 5, anticorps GEMIN5, anticorps Gemin5

Sujet: Synonyms: Background:The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins(snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex.

Poids moléculaire: 168 kDa

ID gène: 25929

UniProt: Q8TEQ6

Pathways: Ribonucleoprotein Complex Subunit Organization