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HTRA1 anticorps

HTRA1 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7115116
  • Antigène Voir toutes HTRA1 Anticorps
    HTRA1 (HtrA Serine Peptidase 1 (HTRA1))
    Reactivité
    • 47
    • 13
    • 10
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 49
    • 1
    Lapin
    Clonalité
    • 50
    Polyclonal
    Conjugué
    • 22
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp HTRA1 est non-conjugé
    Application
    • 33
    • 24
    • 17
    • 11
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)
    Purification
    Immunogen affinity purified
    Pureté
    ≥95 % as determined by SDS-PAGE
    Immunogène
    HtrA serine peptidase 1
    Isotype
    IgG
    Top Product
    Discover our top product HTRA1 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Date de péremption
    12 months
  • Antigène
    HTRA1 (HtrA Serine Peptidase 1 (HTRA1))
    Autre désignation
    HTRA1 (HTRA1 Produits)
    Synonymes
    anticorps htra1, anticorps zgc:92029, anticorps zgc:172061, anticorps l56, anticorps htra, anticorps Xhtra1, anticorps prss11, anticorps MGC145723, anticorps ARMD7, anticorps CARASIL, anticorps HtrA, anticorps L56, anticorps ORF480, anticorps PRSS11, anticorps AI429470, anticorps HTRA, anticorps Prss11, anticorps RSPP11, anticorps HTRA1, anticorps HtrA serine peptidase 1a, anticorps HtrA serine peptidase 1, anticorps HtrA serine peptidase 1b, anticorps Serine protease HTRA1, anticorps HtrA serine peptidase 1 S homeolog, anticorps htra1a, anticorps HTRA1, anticorps htra1b, anticorps htra1, anticorps Htra1, anticorps htra1.S
    Sujet
    Synonyms:HTRA, PRSS11 Background:Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors(IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
    Poids moléculaire
    35 kDa, 50 kD, 42 kDa
    ID gène
    5654
    UniProt
    Q92743
    Pathways
    Growth Factor Binding
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