HTRA1 anticorps

N° du produit ABIN7115116

Détail du produit anti-HTRA1 anticorps

Antigène: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HTRA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: HtrA serine peptidase 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur HTRA1

Antigène: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Autre désignation: HTRA1 (HTRA1 Produits)

Synonymes: anticorps htra1, anticorps zgc:92029, anticorps zgc:172061, anticorps l56, anticorps htra, anticorps Xhtra1, anticorps prss11, anticorps MGC145723, anticorps ARMD7, anticorps CARASIL, anticorps HtrA, anticorps L56, anticorps ORF480, anticorps PRSS11, anticorps AI429470, anticorps HTRA, anticorps Prss11, anticorps RSPP11, anticorps HTRA1, anticorps HtrA serine peptidase 1a, anticorps HtrA serine peptidase 1, anticorps HtrA serine peptidase 1b, anticorps Serine protease HTRA1, anticorps HtrA serine peptidase 1 S homeolog, anticorps htra1a, anticorps HTRA1, anticorps htra1b, anticorps htra1, anticorps Htra1, anticorps htra1.S

Sujet: Synonyms:HTRA, PRSS11 Background:Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors(IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Poids moléculaire: 35 kDa, 50 kD, 42 kDa

ID gène: 5654

UniProt: Q92743

Pathways: Growth Factor Binding