IPO13 anticorps

N° du produit ABIN7115209

Détail du produit anti-IPO13 anticorps

Antigène: IPO13 (Importin 13 (IPO13))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IPO13 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: importin 13

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur IPO13

Antigène: IPO13 (Importin 13 (IPO13))

Autre désignation: IPO13 (IPO13 Produits)

Synonymes: anticorps 3R23, anticorps CG 7212, anticorps CG7212, anticorps Dmel\\CG7212, anticorps Imp13, anticorps imp13, anticorps sd-5, anticorps DDBDRAFT_0205767, anticorps DDBDRAFT_0304414, anticorps DDB_0205767, anticorps DDB_0304414, anticorps DDBDRAFT_0191787, anticorps DDBDRAFT_0304413, anticorps DDB_0191787, anticorps DDB_0304413, anticorps IMP13, anticorps KAP13, anticorps LGL2, anticorps RANBP13, anticorps Kap13, anticorps Ranbp13, anticorps Lgl2, anticorps DKFZp459H088, anticorps cadmus, anticorps importin 13, anticorps cdm, anticorps IPO13, anticorps AFUA_5G08060, anticorps ANI_1_1340034, anticorps AOR_1_1272114, anticorps ipo13B, anticorps ipo13A, anticorps ipo13, anticorps Ipo13

Sujet: Synonyms:KIAA0724, RANBP13 Background:Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex(NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus(By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.

Poids moléculaire: 97kd

ID gène: 9670

UniProt: O94829

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Protein targeting to Nucleus