ISCU anticorps
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- Antigène Voir toutes ISCU Anticorps
- ISCU (Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ISCU est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- Purification
- Immunogen affinity purified
- Pureté
- ≥95 % as determined by SDS-PAGE
- Immunogène
- iron-sulfur cluster scaffold homolog(E. coli)
- Isotype
- IgG
- Top Product
- Discover our top product ISCU Anticorps primaire
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- Indications d'application
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Date de péremption
- 12 months
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- Antigène
- ISCU (Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU))
- Autre désignation
- ISCU (ISCU Produits)
- Sujet
- Synonyms:NIFUN Background:Scaffold protein for the de novo synthesis of iron-sulfur(Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins(PubMed:11060020). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH(By similarity).
- Poids moléculaire
- 14-15 kDa, 18-19 kDa
- ID gène
- 23479
- UniProt
- Q9H1K1
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