KLHL12 anticorps

N° du produit ABIN7115590

Détail du produit anti-KLHL12 anticorps

Antigène: KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KLHL12 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: kelch-like 12(Drosophila)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur KLHL12

Antigène: KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))

Autre désignation: KLHL12 (KLHL12 Produits)

Synonymes: anticorps zgc:92570, anticorps wu:fi60g03, anticorps C3ip1, anticorps C3IP1, anticorps DKIR, anticorps hDKIR, anticorps Ski2 like RNA helicase, anticorps kelch like family member 12 L homeolog, anticorps kelch like family member 12, anticorps kelch-like family member 12, anticorps kelch-like 12, anticorps SKIV2L, anticorps klhl12.L, anticorps KLHL12, anticorps klhl12, anticorps Klhl12

Sujet: Synonyms:C3IP1 Background:Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem(ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31(SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.

Poids moléculaire: 53-56 kDa, 63-67 kDa

ID gène: 59349

UniProt: Q53G59