LATS1 anticorps
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- Antigène Voir toutes LATS1 Anticorps
- LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp LATS1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Purification
- Immunogen affinity purified
- Pureté
- ≥95 % as determined by SDS-PAGE
- Immunogène
- LATS, large tumor suppressor, homolog 1
- Isotype
- IgG
- Top Product
- Discover our top product LATS1 Anticorps primaire
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- Indications d'application
- WB: 1:200-1:1000, IHC: 1:20-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Date de péremption
- 12 months
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- Antigène
- LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
- Autre désignation
- LATS1 (LATS1 Produits)
- Synonymes
- anticorps WARTS, anticorps wts, anticorps AW208599, anticorps Lats, anticorps si:dkey-181i3.5, anticorps wu:fc19a11, anticorps zgc:123219, anticorps lats1, anticorps RGD1564085, anticorps warts, anticorps large tumor suppressor kinase 1, anticorps large tumor suppressor, anticorps large tumor suppressor kinase 1 S homeolog, anticorps LATS1, anticorps Lats1, anticorps lats1, anticorps lats1.S
- Sujet
- Synonyms:LATS1, WARTS, WARTS protein kinase, wts Background:Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
- Poids moléculaire
- 140 kDa
- ID gène
- 9113
- UniProt
- O95835
- Pathways
- Regulation of Actin Filament Polymerization, Maintenance of Protein Location
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