NUMBL anticorps

N° du produit ABIN7117092

Détail du produit anti-NUMBL anticorps

Antigène: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NUMBL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: numb homolog(Drosophila)-like

Clone: 8E0

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur NUMBL

Antigène: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Autre désignation: NUMBL (NUMBL Produits)

Synonymes: anticorps nbl, anticorps numb, anticorps cag3a, anticorps ctg3a, anticorps numbr, anticorps numb-r, anticorps tnrc23, anticorps numblike, anticorps CAG3A, anticorps CTG3a, anticorps NBL, anticorps NUMB-R, anticorps NUMBLIKE, anticorps NUMBR, anticorps TNRC23, anticorps NUMB like, endocytic adaptor protein, anticorps numb homolog-like L homeolog, anticorps NUMB-like, endocytic adaptor protein, anticorps numb-like, anticorps NUMBL, anticorps numbl.L, anticorps Numbl

Sujet: Synonyms: Background:Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells(RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone(SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

Poids moléculaire: 70 kDa

ID gène: 9253

UniProt: Q9Y6R0

Pathways: Cell-Cell Junction Organization