OPTN anticorps

N° du produit ABIN7117124

Détail du produit anti-OPTN anticorps

Antigène: OPTN (Optineurin (OPTN))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OPTN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: optineurin

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP:1:500-1:1000, IHC: 1:50-1:500, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur OPTN

Antigène: OPTN (Optineurin (OPTN))

Autre désignation: OPTN (OPTN Produits)

Synonymes: anticorps nrp, anticorps fip2, anticorps hip7, anticorps hypl, anticorps glc1e, anticorps tfiiia-intp, anticorps ALS12, anticorps FIP2, anticorps GLC1E, anticorps HIP7, anticorps HYPL, anticorps NRP, anticorps TFIIIA-INTP, anticorps Fip2, anticorps 4930441O07Rik, anticorps fj52f04, anticorps si:ch211-240l19.3, anticorps wu:fj52f04, anticorps zgc:66386, anticorps zgc:77868, anticorps optineurin, anticorps optineurin L homeolog, anticorps OPTN, anticorps optn, anticorps Optn, anticorps optn.L

Sujet: Synonyms:FIP2, GLC1E, HIP7, HYPL, NRP Background:Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin(HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor(TFRC/TfR), regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family, targets ubiquitin-coated bacteria(xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. This antibody recognises 66 and 70-74 kDa band, and the additional 70-74 kDa band due to phosphorylation.

Poids moléculaire: 66 kDa

ID gène: 10133

UniProt: Q96CV9

Pathways: M Phase