PTRH2 anticorps

N° du produit ABIN7117297

Détail du produit anti-PTRH2 anticorps

Antigène: PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTRH2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: peptidyl-tRNA hydrolase 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3 ,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur PTRH2

Antigène: PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))

Autre désignation: PTRH2 (PTRH2 Produits)

Synonymes: anticorps BIT1, anticorps PTH2, anticorps A230072I16Rik, anticorps Bit1, anticorps CGI-147, anticorps wu:fj09f02, anticorps zgc:109954, anticorps RGD1306819, anticorps peptidyl-tRNA hydrolase 2, anticorps ptrh2, anticorps CC1G_10259, anticorps ANI_1_1036184, anticorps AOR_1_2082154, anticorps PTRH2, anticorps Ptrh2

Sujet: Synonyms:BIT1, PTH2 Background:The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 20 kDa

ID gène: 51651

UniProt: Q9Y3E5