PLK2 anticorps

N° du produit ABIN7117618

Détail du produit anti-PLK2 anticorps

Antigène: PLK2 (Polo-Like Kinase 2 (PLK2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLK2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: polo-like kinase 2(Drosophila)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur PLK2

Antigène: PLK2 (Polo-Like Kinase 2 (PLK2))

Autre désignation: PLK2 (PLK2 Produits)

Synonymes: anticorps SNK, anticorps hPlk2, anticorps hSNK, anticorps Snk, anticorps PLK2, anticorps Plx2, anticorps MGC53990, anticorps plk2, anticorps zgc:165644, anticorps polo like kinase 2, anticorps polo-like kinase 2, anticorps polo-like kinase 2 L homeolog, anticorps polo-like kinase 2b (Drosophila), anticorps Serine/threonine-protein kinase plk-2, anticorps PLK2, anticorps Plk2, anticorps plk2.L, anticorps plk2b, anticorps plk2, anticorps plk-2

Sujet: Synonyms:SNK Background:Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.

Poids moléculaire: 75-80 kDa

UniProt: Q9NYY3