PSTPIP1 anticorps

N° du produit ABIN7117827

Détail du produit anti-PSTPIP1 anticorps

Antigène: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSTPIP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: proline-serine-threonine phosphatase interacting protein 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3 ,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur PSTPIP1

Antigène: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Autre désignation: PSTPIP1 (PSTPIP1 Produits)

Synonymes: anticorps cd2bp1, anticorps cd2bp1l, anticorps cd2bp1s, anticorps h-pip, anticorps papas, anticorps pstpip, anticorps PSTPIP1, anticorps CD2BP1, anticorps CD2BP1L, anticorps CD2BP1S, anticorps H-PIP, anticorps PAPAS, anticorps PSTPIP, anticorps def-2, anticorps proline-serine-threonine phosphatase interacting protein 1, anticorps proline-serine-threonine phosphatase interacting protein 1 S homeolog, anticorps proline-serine-threonine phosphatase-interacting protein 1, anticorps PSTPIP1, anticorps pstpip1.S, anticorps pstpip1, anticorps Pstpip1

Sujet: Synonyms:CD2BP1 Background:This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.

Poids moléculaire: 48 kDa

ID gène: 9051

UniProt: O43586