RGMA anticorps

N° du produit ABIN7118468

Détail du produit anti-RGMA anticorps

Antigène: RGMA (RGM Domain Family, Member A (RGMA))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RGMA est non-conjugé

Application: ELISA, Western Blotting (WB), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: RGM domain family, member A

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur RGMA

Antigène: RGMA (RGM Domain Family, Member A (RGMA))

Autre désignation: RGMA (RGMA Produits)

Sujet: Synonyms:RGM Background:Member of the repulsive guidance molecule(RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein(BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Poids moléculaire: 49 kDa

ID gène: 56963

UniProt: Q96B86

Pathways: Tube Formation