ARHGEF18 anticorps

N° du produit ABIN7118503

Détail du produit anti-ARHGEF18 anticorps

Antigène: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARHGEF18 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: rho/rac guanine nucleotide exchange factor(GEF) 18

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur ARHGEF18

Antigène: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Autre désignation: ARHGEF18 (ARHGEF18 Produits)

Synonymes: anticorps arhgef18, anticorps wu:fc21e04, anticorps wu:fj05f11, anticorps zgc:85686, anticorps P114-RhoGEF, anticorps AI467246, anticorps D030053O22Rik, anticorps rho/rac guanine nucleotide exchange factor (GEF) 18a, anticorps Rho/Rac guanine nucleotide exchange factor (GEF) 18, anticorps Rho/Rac guanine nucleotide exchange factor 18, anticorps rho guanine nucleotide exchange factor 18, anticorps rho/rac guanine nucleotide exchange factor (GEF) 18, anticorps arhgef18a, anticorps ARHGEF18, anticorps LOC100027283, anticorps Arhgef18

Sujet: Synonyms:KIAA0521 Background:Acts as guanine nucleotide exchange factor(GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species(ROS). Does not act as a GEF for CDC42. The G protein beta-gamma(Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells(PubMed:22006950).

Poids moléculaire: 120-130 kDa

ID gène: 23370

UniProt: Q6ZSZ5

Pathways: Neurotrophin Signaling Pathway